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| 30,000 B.C. | Asians begin migrating to North America across the Bering Strait |
| 1000 A.D. | Norsemen set up temporary settlement in Newfoundland |
| 1420s | Portuguese explorers travel down the west coast of Africa in search of sea route to Asia |
| 1492 | Columbus, seeking a western route to Asia, reaches san Salvador Island in the Caribbean |
| 1493 | Syphilis first recorded in Europe |
| 1494 | Treaty of Tordesillas divides New World between Spain and Portugal |
| 1497 | John Cabot establishes first English claim in North America |
| 1513 | Ponce de Leon arrives on Florida mainland Balboa reaches Pacific Ocean by crossing Isthmus of Panama |
| 1517 | Martin Luther challenges Roman Catholic authority, beginning Protestant Reformation in Europe |
| 1518 | Smallpox epidemic begins devastating Indian populatio |
| 1521 | Cortes conquers Aztecs in Mexico Magellan circumnavigates the globe |
| 1524 | Verrazano explores North American coast |
| 1533 | Pizarro captures Inca capital in Peru |
| 1539 | de Soto explores southeast U.S. |
| 1540 | Coronado explores southwest U.S. |
| 1558 | Elizabeth I takes throne in England |
| 1585 | Roanoke Island colony established, then disappears |
| 1603 | James I takes throne in England |
Feldmeth, Greg D. "U.S. History Resources"
http://home.earthlink.net/~gfeldmeth/USHistory.html (31 March 1998).
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